| Gamecock Athletes | | Name | Begin | End | City | State | Sport |
| Jessie Uecker | 2001 | 2001 | | | Soccer; |
| Petra Ujhelyi | 1999 | 2003 | Budapest | | Basketball; |
| Desmond Umeozulu | 2023 | 2023 | Upper Marlboro | MD | Football; |
| Bobby Underwood | 1987 | 1988 | Fort Lawn | SC | Baseball; |
| Harry Underwood | 1963 | 1963 | Smithfield | VA | Football; |
Joey Unitas | 1995 | 1997 | Baldwin | MD | Football; | Nikki Unroe | 1997 | 2000 | | | Swimming/Diving; | William Unseld | 1994 | 1995 | Bowling Green | OH | Basketball; | Pete Unsworth | 1967 | 1967 | Norfolk | VA | Football; | Daniel Upchurch | 2004 | 2007 | Dallas | TX | Soccer; | | Dan Upton | 1960 | 1960 | | | Track & Field; |
| Jim Upton | 1960 | 1960 | | | Track & Field; |
| Alex (Jeep) Urban | 1938 | 1940 | Bessemer | PA | Football; |
| Frank Urban | 1936 | 1938 | Toledo | OH | Football; |
| Kelsey Urban | 2012 | 2016 | East Hampton | CT | Equestrian; |
Don Urbanciz | 1968 | 1969 | | | Baseball; | Art Urbanyi | 1936 | 1937 | Toledo | OH | Football; | Jay Urich | 2017 | 2020 | Greenville | SC | Football; | Derrick Urquhart | 1995 | 1998 | Florence | SC | Baseball; | Jim Urquhart | 1933 | 1933 | | | Football; | | Maceon Urueta | 2018 | 2018 | Taylors | SC | Soccer; |
| Al Usher | 1967 | 1971 | Pageland | SC | Football; |
| Jimmy Usher | 1958 | 1958 | Bennettsville | SC | Baseball; |
| John Usher | 1970 | 1972 | Pageland | SC | Football; |
| Trent Usher | 2004 | 2005 | Pageland | SC | Football; |
Ashley Usry | 1998 | 1998 | | | Swimming/Diving; | Mary Claire Utsey | 2002 | 2004 | | | Track & Field; | Anita Uwadia | 2016 | 2020 | Newcastle | | Golf; |