| Players | |||||
|---|---|---|---|---|---|
| Name | Pos | Begin | End | City | State |
| Justin Dalles | C | 2009 | 2009 | Lake Worth | FL |
| Matt Danner | OF | 1997 | 1998 | ||
| R.J. Dantin | P | 2020 | 2020 | Spartanburg | SC |
| L.B. Dantzler | 3B | 2012 | 2013 | Winter Haven | FL |
| James Darnell | IF | 2006 | 2008 | Danville | CA | Joe Datin | 1B | 1985 | 1986 | Cincinnati | OH | . Davis | P | 1943 | 1943 | . Davis | OF | 1929 | 1929 | Bill Davis | C | 1951 | 1951 | Clement Davis | OF | 1900 | 1903 | Winnsboro | SC |
| J.W. Davis | 1918 | 1918 | Choudrant | LA | |
| John Davis | SS | 1906 | 1908 | Winnsboro | SC |
| James Dean | OF | 1950 | 1950 | Cost Point | GA |
| Walker Dean | C | 1988 | 1988 | Elon | NC |
| Rob DeBoer | C | 1990 | 1994 | Omaha | NE | Billy DeBruhl | P | 1960 | 1960 | Robert DeCosmo | P | 2012 | 2012 | Agawam | MS | Brennan Dees | OF | 2000 | 2000 | Montgomery | AL | Paul DeLaVerre | P | 1977 | 1977 | Croton-on-Hudson | NY | Trey Delk | P | 2005 | 2005 | Elgin | SC |
| Angelo DeMario | OF | 1940 | 1941 | Ironwood | MI |
| Chase DeMars | SS | 2017 | 2017 | Overland Park | KS |
| Eddy Demurias | P | 2018 | 2018 | Miami | FL |
| Julius Derrick | OF | 1954 | 1957 | Columbia | SC |
| U.G. Desportes | 1908 | 1910 | Winnsboro | SC | Alex Destino | OF | 2015 | 2017 | Weaverville | NC | Frank Destino | OF | 1955 | 1958 | Gloucester | MA | Mike Dezenzo | OF | 1992 | 1995 | Alliance | OF | Chris Diaz | 1B | 1993 | 1995 | Atlanta | GA | Anthony Dick | 1923 | 1923 |
| L.C. Dickert | OF | 1925 | 1925 | ||
| Joseph Dickson | C | 1903 | 1905 | Manning | SC |
| Emmett Dietz | C | 1951 | 1952 | Asheville | NC |
| Phil Disher | C | 2005 | 2008 | Aiken | SC |
| Cliff Donald | P | 2002 | 2005 | Anderson | SC | Jerry Donald | P | 1957 | 1958 | Spartanburg | SC | Earl Donaldson | P | 1956 | 1956 | Bill Donelan | OF | 1929 | 1930 | Columbia | SC | Phil Donlin | P | 1956 | 1956 | Montclair | NJ | Jack Dorr | C | 1950 | 1951 | Blackville | SC |
| Craig Dour | SS | 1994 | 1997 | Tarpon Springs | FL |
| Everett Driver | P | 1945 | 1946 | ||
| Morgan DuBose | P | 1906 | 1906 | Columbia | SC |
| Pierce DuBose | P | 1912 | 1912 | ||
| Fred Duckett | OF | 1950 | 1953 | Union | SC | . Duckworth | 1917 | 1917 | Sam Dudevski | P | 1976 | 1976 | Syracuse | NY | Elzie Dudley | 1923 | 1924 | Chester Duke | 3B | 1960 | 1960 | Columbia | SC | Earl Dunham | OF | 1940 | 1946 | Macon | GA |
| Donnie Dunlap | OF | 1964 | 1966 | Columbia | SC |
| Burl (Lit) Durham | 1936 | 1937 | Greenville | SC | |
| Earl (Big) Durham | OF | 1936 | 1938 | Greenville | SC |
| Barney Dusenbury | OF | 1948 | 1949 | Florence | SC |
| Dick Dusenbury | P | 1945 | 1945 | Florence | SC | William Duval | 1903 | 1904 | Cheraw | SC | Sam Dyson | P | 2008 | 2010 | Tampa | FL | Trey Dyson | 1B | 1999 | 2002 | Columbia | SC |