| Players | |||||
|---|---|---|---|---|---|
| Name | Pos | Begin | End | City | State |
| Michael Saccone | 1996 | 1996 | |||
| . Sadler | 1911 | 1911 | |||
| Graham Saiko | OF | 2013 | 2013 | Newburgh | IN |
| Kenneth Salley | OF | 1926 | 1928 | ||
| Dudley (Country Sanders | 1921 | 1923 | Columbia | SC | Will Sanders | P | 2022 | 2022 | Atlanta | GA | Alex Satterfield | P | 2013 | 2013 | Laurens | SC | Joe Satterfield | 1B | 2021 | 2021 | Greenville | SC | Clint Sawyer | P | 1985 | 1986 | Georgetown | SC | Dan Scarpa | C | 1965 | 1967 | Derby | CT |
| . Schacte | 1916 | 1916 | |||
| Clarke Schmidt | P | 2015 | 2017 | Acworth | GA |
| Max Schrock | 2B | 2013 | 2015 | Chapel Hill | NC |
| Clark Scolamiero | OF | 2015 | 2016 | Simpsonville | SC |
| . Scott | 1927 | 1927 | Aaron Scott | P | 1978 | 1979 | Mitchell Scott | C | 1947 | 1950 | Pike Road | AL | Reed Scott | P | 2014 | 2017 | Roswell | GA | Scotty Scott | P | 1926 | 1928 | Lake View | SC | Cole Seaborn | C | 1916 | 1920 | Pickens | SC |
| McClendon Sears | IF | 2018 | 2018 | Sumter | SC |
| . Seath | C | 1948 | 1948 | ||
| Tim Seaton | OF | 2002 | 2003 | Tampa | FL |
| Joel Seddon | P | 2012 | 2013 | St. Clair | MI |
| Si Seideman | 1924 | 1927 | Charles Seoane | P | 1986 | 1988 | Tampa | FL | Patrick Sexton | P | 1996 | 1998 | Monroe Shand | 1899 | 1900 | Columbia | SC | . Shaw | 1943 | 1943 | H.B. Shaw | 1910 | 1910 |
| Jimmy Shea | OF | 1952 | 1954 | ||
| Walt Shea | 1B | 1948 | 1952 | Brooklyn | NY |
| Grady Shelley | OF | 1960 | 1960 | ||
| . Shelton | OF | 1925 | 1925 | ||
| Jerry Shepherd | OF | 1991 | 1992 | Lizella | GA | Frank Sherer | P | 1947 | 1950 | Sharon | SC | Shane Shifflet | IF | 2020 | 2020 | Venice | FL | T.J. Shook | P | 2017 | 2019 | Columbia | SC | Bunky Shore | 3B | 1956 | 1960 | Winston-Salem | NC | John Shuler | 3B | 1913 | 1914 | Vance | SC |
| Ken Shull | OF | 1972 | 1974 | West Columbia | SC |
| Dan Siau | C | 1986 | 1986 | Georgeown | SC |
| Josiah Sightler | 1B | 2019 | 2019 | Gaston | SC |
| Eddie Sikes | 1B | 1930 | 1931 | ||
| John Simmons | C | 1981 | 1981 | Cayce | SC | Charles Simpson | P | 1906 | 1909 | Laurens | SC | F.W. Simpson | 1910 | 1910 | Sam Simpson | P | 2022 | 2022 | Carrollton | GA | Frank Simrill | OF | 1916 | 1917 | Chad Sims | 2B | 1989 | 1989 | Brooksville | FL |
| Cy Sims | P | 1915 | 1917 | ||
| Lana Sims | 2B | 1915 | 1919 | ||
| Mike Siopes | P | 1987 | 1988 | Raleigh | NC |
| Mike Sisk | 3B | 1972 | 1974 | Columbia | SC |
| Walter Sizemore | OF | 1920 | 1923 | Rock Hill | SC | Johnny Skalangya | 2B | 1944 | 1946 | Carteret | NJ | Rube Skinner | SS | 1918 | 1920 | Sumter | SC | Strother Sligh | OF | 1966 | 1966 | Columbia | SC | David Small | IF | 1974 | 1977 | Atlanta | GA | Hank Small | 1B | 1972 | 1975 | Atlanta | GA |
| Martin Small | P | 1979 | 1981 | Atlanta | GA |
| . Smith | SS | 1915 | 1915 | ||
| Bobby Smith | 1B | 1924 | 1926 | ||
| Bobby Smith | 2B | 1961 | 1962 | ||
| Claude Smith | OF | 1911 | 1912 | D.J. Smith | C | 2004 | 2004 | Hopkins | SC | Demetric Smith | 1B | 1999 | 2003 | Rock Hill | SC | Harrison Smith | P | 2016 | 2016 | Mount Pleasant | SC | Hyde Smith | OF | 1919 | 1919 | Jackson Smith | P | 2014 | 2014 | Hartselle | AL |
| Jimbo Smith | P | 1968 | 1970 | ||
| Lamar Smith | C | 1952 | 1952 | ||
| Larry Smith | 1949 | 1951 | Ford City | PA | |
| Lewis Smith | 2B | 1907 | 1909 | Spartanburg | SC |
| Sydney Smith | C | 1902 | 1903 | Thomas Smith | C | 1928 | 1930 | Anderson | SC | Justin Smoak | 1B | 2006 | 2008 | Goose Creek | SC | Dave Smyth | OF | 1986 | 1987 | Winsted | CT | . Snipes | 1916 | 1916 | Roxy Snipes | OF | 1922 | 1924 | Marion | SC |
| Fred Snoddy | P | 1942 | 1947 | Greenville | SC |
| Mike Songini | 3B | 1987 | 1988 | East Longmeadow | MA |
| Tom Sotack | P | 1977 | 1977 | Hershey | PA |
| . Spahr | 1896 | 1896 | |||
| Herman Spahr | OF | 1900 | 1902 | Orangeburg | SC | Tyler Speer | P | 1997 | 1997 | David Spence | P | 1972 | 1974 | Lexington | SC | Chris Spigner | P | 1999 | 2002 | Hopkins | SC | Tony Spires | P | 1988 | 1989 | Pelion | SC | Al Spotts | 1B | 1951 | 1954 | Newberry | SC |
| Jim St. Laurent | OF | 1983 | 1984 | Swanzey Center | NH |
| Craig Stamey | C | 1987 | 1988 | Charleston | SC |
| Jack Stamler | P | 2018 | 2018 | Greenville | SC |
| John Stamper | 1997 | 2001 | Andrews | SC | |
| Don Stanley | 1968 | 1970 | Mark Stanley | OF | 2003 | 2006 | Columbia | SC | Eric Stanton | 1B | 1996 | 1998 | Newberry | SC | Marcus Stark | 1941 | 1942 | Timmonsville | SC | . Starr | 1927 | 1927 | Collin Steagall | 1B | 2015 | 2015 | Lexington | SC |
| Randy Stegall | 3B | 1994 | 1995 | Orlando | FL |
| Andy Stein | P | 1990 | 1991 | West Columbia | SC |
| Kent Stein | P | 1993 | 1993 | West Columbia | SC |
| Billy Stephens | 3B | 1949 | 1952 | Wrightsville | GA |
| Charles (Rusty) Stephens | 2B | 1949 | 1949 | Charlie Stephenson | 2B | 1948 | 1951 | Charleston | SC | . Stewart | SS | 1943 | 1943 | Buddy Stewart | 2B | 1954 | 1954 | Bob Stoddard | P | 1927 | 1929 | Columbia | SC | Hugh Stoddard | OF | 1928 | 1930 | Columbia | SC |
| Ernie Stokes | 1935 | 1935 | |||
| Jackie Stokes | P | 1967 | 1967 | ||
| Johnny Stokes | OF | 1950 | 1952 | Darlington | SC |
| Madison Stokes | SS | 2015 | 2018 | Columbia | SC |
| Pete Stokes | SS | 1956 | 1958 | Darlington | SC | Stacy Stokes | 2B | 1990 | 1994 | Camden | SC | Tom Stokes | P | 1990 | 1991 | Columbia | SC | . Stone | C | 1944 | 1944 | Corey Stone | P | 2018 | 2018 | Prosperity | SC | Evan Stone | OF | 2022 | 2022 | Irmo | SC |
| Jerry Stone | 1B | 1960 | 1961 | St. Matthews | SC |
| Burnet Stoney | C | 1910 | 1915 | Camden | SC |
| Jim Stoops | P | 1992 | 1995 | Somerset | NJ |
| Mason Streater | IF | 2018 | 2018 | Duncan | SC |
| Rob Streicher | C | 1996 | 1997 | Boca Raton | FL | Mickey Strickland | OF | 1960 | 1960 | Greer | SC | Scotty Strong | OF | 1995 | 1995 | Irmo | SC | Heber (Rock) Stroud | 3B | 1937 | 1940 | Darlington | SC | John Sullivan | 3B | 1981 | 1984 | Grand Island | NY | Patrick Sullivan | P | 2010 | 2013 | Columbia | SC |
| Sean Sullivan | OF | 2012 | 2013 | Columbia | SC |
| Ben Suttle | 1944 | 1944 | Shelby | NC | |
| Wesley Sweatt | P | 2019 | 2019 | Rock Hill | SC |
| Paul Sweezy | OF | 1949 | 1950 | Braintree | MA |
| Jeff Swindell | 2B | 1982 | 1982 | Sarasota | FL | Marion Swink | SS | 1923 | 1926 | Woodruff | SC | Will Swink | C | 1925 | 1928 | Woodruff | SC | Bud Swygert | P | 1959 | 1961 | Graniteville | SC | John Swygert | SS | 1906 | 1906 | Columbia | SC | John Sykes | SS | 1947 | 1950 | Raleigh | NC |
| John (Cy) Szakacsi | 1B | 1946 | 1950 | Fairport Harbor | OH |
| Ryan Szwejbka | 2B | 1994 | 1997 | Fairport | NY |