| 2006 Results | | Date | Result | SC W/L | SC Save | Location | Game Type | SC HR |
| 02/10 | #14 South Carolina 5, Elon 4 | S.Valdes-Fauli (W, 1-0) | | Columbia, SC | | |
| 02/11 | Elon 2, #14 South Carolina 1 | A.Hempy (L, 0-1) | | Columbia, SC | | N.Gielser (1) |
| 02/12 | #14 South Carolina 8, Elon 3 | F.Beverly (W, 1-0) | | Columbia, SC | | J.Darnell (1), I.Paxton (1) |
| 02/17 | #13 South Carolina 7, Radford 0 | A.Lambert (W, 1-0) | | Columbia, SC | | R.Grinestaff 2(2) |
| 02/18 | #13 South Carolina 5, Radford 2 | A.Cruse (W, 1-0) | S.Valdes-Fauli (1) | Columbia, SC | | |
| 02/19 | #13 South Carolina 2, Radford 0 | F.Beverly (W, 2-0) | S.Valdes-Fauli (2) | Columbia, SC | | N.Gielser (2) |
| 02/24 | #13 South Carolina 15, Duquesne 0 | D.Luczak (W, 1-0) | | Columbia, SC | | C.Hurst (1), R.Grinestaff (3) |
| 02/26 | #13 South Carolina 6, Duquesne 3 | A.Lambert (W, 2-0) | S.Valdes-Fauli (3) | Columbia, SC | | R.Grinestaff (4) |
| 02/26 | #13 South Carolina 12, Duquesne 4 | F.Beverly (W, 3-0) | | Columbia, SC | | J.Smoak (1) |
| 03/04 | #9 South Carolina 6, #1 Clemson 2 | A.Cruse (W, 2-0) | | Columbia, SC | | R.Grinestaff (5) |
| 03/05 | #1 Clemson 6, #9 South Carolina 4 | A.Lambert (L, 2-1) | | Clemson, SC | | |
| 03/07 | #9 South Carolina 8, William & Mary 1 | H.Honeycutt (W, 1-0) | | Columbia, SC | | |
| 03/10 | #9 South Carolina 10, Quinnipac 4 | A.Hempy (W, 1-1) | | Columbia, SC | | C.Brown (1), A.Crisp (1) |
| 03/11 | #9 South Carolina 12, Quinnipac 0 | M.Cisco (W, 1-0) | | Columbia, SC | | J.Willard (1) |
| 03/12 | #9 South Carolina 9, Quinnipac 2 | F.Beverly (W, 4-0) | | Columbia, SC | | D.Martin (1), J.Smoak (2), I.Paxton (2) |
| 03/14 | #9 South Carolina 9, Davidson 2 | H.Honeycutt (W, 2-0) | | Columbia, SC | | C.Brown (2), R.Havens (1) |
| 03/15 | #9 South Carolina 8, Yale 2 | W.Atwood (W, 1-0) | | Columbia, SC | | J.Smoak (3) |
| 03/17 | #9 South Carolina 12, Auburn 8 | W.Pelzer (W, 1-0) | | Auburn, AL | SEC | |
| 03/18 | #9 South Carolina 7, Auburn 3 | M.Cisco (W, 2-0) | | Auburn, AL | SEC | T.Kline (1) |
| 03/19 | Auburn 7, #9 South Carolina 1 | F.Beverly (L, 4-1) | | Auburn, AL | SEC | M.Campbell (1) |
| 03/21 | #7 South Carolina 6, Charleston Southern 3 | W.Atwood (W, 2-0) | W.Pelzer (1) | Columbia, SC | | D.Martin (2) |
| 03/22 | #7 South Carolina 11, Furman 3 | H.Honeycutt (W, 3-0) | | Columbia, SC | | T.Kline (2) |
| 03/24 | #7 South Carolina 4, #9 Florida 1 | A.Hempy (W, 2-1) | A.Cruse (1) | Columbia, SC | SEC | |
| 03/25 | #7 South Carolina 6, #9 Florida 5 | M.Cisco (W, 3-0) | W.Pelzer (2) | Columbia, SC | SEC | R.Grinestaff (6) |
| 03/26 | #7 South Carolina 21, #9 Florida 4 | F.Beverly (W, 5-1) | | Columbia, SC | SEC | C.Hurst (2), R.Grinestaff 2(8), I.Paxton (3) |
| 03/28 | #5 South Carolina 13, Wofford 1 | D.Luczak (W, 2-0) | | Columbia, SC | | M.Stanley (1) |
| 03/31 | #5 South Carolina 12, #15 LSU 2 | A.Cruse (W, 3-0) | | Baton Rouge, LA | SEC | N.Giesler (3), J.Smoak (4) |
| 04/01 | #5 South Carolina 18, #15 LSU 4 | M.Cisco (W, 4-0) | | Baton Rouge, LA | SEC | M.Campbell (2), R.Grinestaff (9), J.Smoak (5), T.Kline (3) |
| 04/02 | #5 South Carolina 2, #15 LSU 1 | W.Pelzer (W, 2-0) | | Baton Rouge, LA | SEC | |
| 04/05 | #7 Clemson 3, #1 South Carolina 2 | C.Lalor (L, 0-1) | | Columbia, SC | | R.Grinestaff (10) |
| 04/07 | #1 South Carolina 7, #10 Alabama 6 | W.Pelzer (W, 3-0) | | Columbia, SC | SEC | |
| 04/09 | #10 Alabama 8, #1 South Carolina 6 | F.Beverly (L, 5-2) | | Columbia, SC | SEC | C.Hurst (3), R.Grinestaff (11), D.Martin (3) |
| 04/09 | #10 Alabama 6, #1 South Carolina 1 | A.Lambert (L, 2-2) | | Columbia, SC | SEC | J.Smoak (6) |
| 04/12 | #5 Clemson 10, #7 South Carolina 5 | A.Cruse (L, 3-1) | | Clemson, SC | | J.Darnell (2) |
| 04/14 | #7 South Carolina 1, Mississippi 0 | M.Cisco (W, 5-0) | W.Pelzer (3) | Columbia, SC | SEC | A.Crisp (2) |
| 04/15 | #7 South Carolina 6, Mississippi 3 | A.Cruse (W, 4-1) | W.Pelzer (4) | Columbia, SC | SEC | J.Smoak (7), A.Crisp (3) |
| 04/16 | Mississippi 11, #7 South Carolina 6 | C.Tucker (L, 0-1) | | Columbia, SC | SEC | M.Campbell (3), T.Kline (4) |
| 04/19 | #7 South Carolina 11, Citadel 2 | W.Atwood (W, 3-0) | | Columbia, SC | | R.Havens (2), I.Paxton (4), R.Grinestaff (12), J.Willard (2) |
| 04/21 | #21 Kentucky 10, #7 South Carolina 9 | W.Pelzer (L, 3-1) | | Lexington, KY | SEC | J.Willard (3) |
| 04/22 | #21 Kentucky 15, #7 South Carolina 12 | A.Cruse (L, 4-2) | | Lexington, KY | SEC | J.Smoak (8) |
| 04/23 | #21 Kentucky 12, #7 South Carolina 9 | K.Brown (L, 0-1) | A.Albers (1) | Lexington, KY | SEC | A.Crisp (4) |
| 04/28 | #12 South Carolina 11, #17 Mississippi State 5 | W.Pelzer (W, 4-1) | | Columbia, SC | SEC | R.Havens (3), J.Smoak 2(10), M.Stanley (2) |
| 04/29 | #17 Mississippi State 7, #12 South Carolina 2 | M.Cisco (L, 5-1) | | Columbia, SC | SEC | |
| 04/30 | #12 South Carolina 9, #17 Mississippi State 7 | A.Farotto (W, 1-0) | | Columbia, SC | SEC | J.Willard (4), M.Campbell (4) |
| 05/03 | Wofford 9, #10 South Carolina 8 | A.Cruse (L, 4-3) | | Spartanburg, SC | | J.Willard (5) |
| 05/05 | Georgia 8, #10 South Carolina 4 | W.Pelzer (L, 4-2) | | Athens, GA | SEC | C.Brown (3), R.Grinestaff (13) |
| 05/06 | Georgia 7, #10 South Carolina 5 | M.Cisco (L, 5-2) | | Athens, GA | SEC | J.Smoak (11) |
| 05/07 | Georgia 7, #10 South Carolina 4 | W.Atwood (L, 3-1) | | Athens, GA | SEC | J.Smoak (12) |
| 05/09 | #15 South Carolina 12, Citadel 3 | H.Honeycutt (W, 4-0) | | Charleston, SC | | C.Brown (4) |
| 05/12 | Tennessee 5, #15 South Carolina 4 | W.Pelzer (L, 4-3) | | Columbia, SC | SEC | |
| 05/13 | Tennessee 8, #15 South Carolina 7 | M.Cisco (L, 5-3) | | Columbia, SC | SEC | J.Smoak (13), J.Willard (6) |
| 05/14 | #15 South Carolina 9, Tennessee 2 | W.Atwood (W, 4-1) | | Columbia, SC | SEC | C.Hurst (4) |
| 05/16 | #17 South Carolina 15, Furman 12 | F.Beverly (W, 6-2) | | Columbia, SC | | R.Grinestaff (14) |
| 05/18 | Vanderbilt 8, #17 South Carolina 7 | M.Cisco (L, 5-4) | | Nashville, TN | SEC | J.Smoak (14), R.Grinestaff (15) |
| 05/19 | Vanderbilt 10, #17 South Carolina 6 | W.Atwood (L, 4-2) | | Nashville, TN | SEC | J.Smoak (15) |
| 05/20 | #17 South Carolina 6, Vanderbilt 3 | H.Honeycutt (W, 5-0) | A.Cruse (2) | Nashville, TN | SEC | P.Disher (1) |
| 05/24 | #23 South Carolina 4, #7 Kentucky 2 | M.Cisco (W, 6-4) | W.Pelzer (5) | Hoover, AL | SEC Tournament | J.Willard (7) |
| 05/25 | Vanderbilt 11, #23 South Carolina 1 | J.Jeffords (L, 0-1) | | Hoover, AL | SEC Tournament | |
| 05/26 | #9 Georgia 16, #23 South Carolina 10 | W.Pelzer (L, 4-4) | | Hoover, AL | SEC Tournament | J.Smoak (16), P.Disher (2), I.Paxton (5) |
| 06/03 | South Carolina 4, Evansville 2 | M.Cisco (W, 7-4) | | Charlottesville, VA | NCAA Regional | |
| 06/03 | South Carolina 8, Virginia 2 | H.Honeycutt (W, 6-0) | A.Cruse (3) | Charlottesville, VA | NCAA Regional | P.Disher (3) |
| 06/04 | Evansville 15, South Carolina 5 | F.Beverly (L, 6-3) | | Charlottesville, VA | NCAA Regional | P.Disher (4), A.Crisp (5) |
| 06/05 | South Carolina 5, Evansville 1 | W.Pelzer (W, 5-4) | | Charlottesville, VA | NCAA Regional | P.Disher (5) |
| 06/10 | South Carolina 15, Georgia 6 | H.Honeycutt (W) | | Athens, GA | NCAA Super Regional | N.Giesler, J.Smoak, P.Disher, An.Crisp 2, R.Grinestaff 2, J.Darnell |
| 06/11 | Georgia 11, South Carolina 5 | M.Cisco (L, 7-5) | | Athens, GA | NCAA Super Regional | |
| 06/12 | Georgia 11, South Carolina 6 | W.Pelzer (L, 5-3) | | Athens, GA | NCAA Super Regional | C.Brown (5), R.Havens (4) |