| 2010 Results | | Date | Result | SC W/L | SC Save | Location | Game Type | SC HR |
| 02/19 | #10 South Carolina 10, Duquesne 3 | B.Cooper (W, 1-0) | | Columbia, SC | | C.Walker (1), J.Jones 2(2) |
| 02/20 | #10 South Carolina 13, Duquesne 3 | S.Dyson (W, 1-0) | | Columbia, SC | | C.Walker (2), J.Jones (3) |
| 02/21 | #10 South Carolina 5, Duquesne 3 | S.Neff (W, 1-0) | | Columbia, SC | | A.Matthews (1) |
| 02/26 | #10 South Carolina 6, #13 East Carolina 2 | B.Cooper (W, 2-0) | J.Taylor (1) | Greenville, NC | | |
| 02/27 | #13 East Carolina 4, #10 South Carolina 3 | J.Taylor (L, 0-1) | | Greenville, NC | | |
| 02/28 | #13 East Carolina 4, #10 South Carolina 2 | S.Neff (L, 1-1) | | Greenville, NC | | |
| 03/03 | #15 South Carolina 15, Presbyterian 0 | N.Belcher (W, 1-0) | | Columbia, SC | | W.Merrifield (1), S.Wingo (1) |
| 03/05 | #9 Clemson 4, #15 South Carolina 3 | M.Roth (L, 0-1) | | Clemson, SC | | |
| 03/06 | #15 South Carolina 7, #9 Clemson 5 | M.Price (W, 1-0) | M.Roth (1) | Greenville, SC | | J.Bradley (1) |
| 03/07 | #9 Clemson 19, #15 South Carolina 6 | T.Webb (L, 0-1) | | Columbia, SC | | S.Wingo (2) |
| 03/09 | #19 South Carolina 12, Valparaiso 4 | J.Mata (W, 1-0) | | Columbia, SC | | W.Merrfield (2) |
| 03/10 | #19 South Carolina 7, Valparaiso 3 | M.Price (W, 2-0) | | Columbia, SC | | |
| 03/13 | #19 South Carolina 8, Brown 4 | B.Cooper (W, 3-0) | | Columbia, SC | | P.Bangs (1) |
| 03/13 | #19 South Carolina 10, Brown 7 | J.Brown (W, 1-0) | M.Roth (2) | Columbia, SC | | W.Merrifield (3) |
| 03/14 | #19 South Carolina 6, Brown 5 | J.Revan (W, 1-0) | | Columbia, SC | | N.Ebert (1) |
| 03/16 | #16 South Carolina 15, Furman 0 | N.Belcher (W, 2-0) | | Greenville, SC | | |
| 03/17 | #16 South Carolina 8, Davidson 3 | J.Mata (W, 2-0) | | Columbia, SC | | |
| 03/19 | #16 South Carolina 4, Tennessee 2 | E.Carter (W, 1-0) | | Columbia, SC | SEC | A.Morales (1) |
| 03/20 | #16 South Carolina 10, Tennessee 7 | P.Bangs (W, 1-0) | | Columbia, SC | SEC | W.Merrifield (4), J.Jones (4) |
| 03/21 | #16 South Carolina 4, Tennessee 0 | T.Webb (W, 1-1) | M.Price (1) | Columbia, SC | SEC | W.Merrifield (5), S.Wingo (3) |
| 03/23 | South Carolina 8, Georgia Southern 5 | J.Taylor (W, 1-1) | | Statesboro, GA | | B.Thomas (1) |
| 03/26 | #14 South Carolina 11, Auburn 5 | B.Cooper (W, 4-0) | | Auburn, AL | SEC | P.Bangs (2), A.Matthews (2), S.Wingo (4) |
| 03/27 | #14 South Carolina 2, Auburn 0 | S.Dyson (W, 2-0) | M.Price (2) | Auburn, AL | SEC | |
| 03/28 | Auburn 10, #14 South Carolina 6 | T.Webb (L, 1-2) | | Auburn, AL | SEC | |
| 03/30 | #12 South Carolina 10, #25 Citadel 1 | C.Holmes (W, 1-0) | | Columbia, SC | | J.Bradley (2), J.Jones (5), R.Beary (1), M.Roth (1) S.Wingo (5) |
| 04/02 | #12 South Carolina 10, Mississippi State 2 | B.Cooper (W, 5-0) | | Columbia, SC | SEC | B.Thomas 2(3) |
| 04/03 | Mississippi State 8, #12 South Carolina 7 | S.Dyson (L, 2-1) | | Columbia, SC | SEC | W.Merrifield (6) |
| 04/04 | #12 South Carolina 14, Mississippi State 2 | M.Price (W, 3-0) | | Columbia, SC | SEC | P.Bangs (3), N.Ebert (2), A.Morales (2) |
| 04/07 | #8 South Carolina 6, College of Charleston 3 | C.Holmes (W, 2-0) | M.Roth (3) | Columbia, SC | SEC | N.Ebert (3) |
| 04/09 | #8 South Carolina 3, #19 Vanderbilt 2 | B.Cooper (W, 6-0) | M.Price (3) | Nashville, TN | SEC | |
| 04/10 | #19 Vanderbilt 8, #8 South Carolina 2 | S.Dyson (L, 2-2) | | Nashville, TN | SEC | |
| 04/11 | #8 South Carolina 2, #19 Vanderbilt 0 | J.Brown (W, 2-0) | M.Price (4) | Nashville, TN | SEC | W.Merrifield (7) |
| 04/14 | #5 South Carolina 10, Citadel 4 | J.Taylor (W, 2-1) | | Charleston, SC | | S.Wingo 2(7) |
| 04/16 | #5 South Carolina 5, #14 Mississippi 0 | B.Cooper (W, 7-0) | | Columbia, SC | SEC | |
| 04/17 | #5 South Carolina 9, #14 Mississippi 5 | S.Dyson (W, 3-2) | E.Carter (1) | Columbia, SC | SEC | C.Walker (3), B.Thomas (4) |
| 04/18 | #14 Mississippi 5, #5 South Carolina 4 | J.Taylor (L, 2-2) | | Columbia, SC | SEC | A.Matthews (3), S.Wingo (8) |
| 04/20 | South Carolina 4, USC-Upstate 2 | J.Mata (W, 3-0) | E.Carter (2) | Columbia, SC | | |
| 04/23 | #5 South Carolina 11, Georgia 4 | B.Cooper (W, 8-0) | | Athens, GA | SEC | W.Merrifield (8), A.Matthews (4) |
| 04/25 | #5 South Carolina 5, Georgia 0 | S.Dyson (W, 4-2) | | Athens, GA | SEC | N.Ebert (4), A.Morales (3) |
| 04/25 | #5 South Carolina 8, Georgia 7 | E.Carter (W, 2-0) | | Athens, GA | SEC | J.Bradley (3), A.Morales (4) |
| 04/30 | #3 South Carolina 9, Alabama 7 | J.Mata (W, 4-0) | | Columbia, SC | SEC | J.Bradley (4), J.Jones (6), B.Thomas (5), S.Wingo (9) |
| 05/01 | Alabama 6, #3 South Carolina 4 | S.Dyson (L, 4-3) | | Columbia, SC | SEC | C.Walker (4) |
| 05/02 | #3 South Carolina 20, Alabama 15 | T.Webb (W, 2-2) | | Columbia, SC | SEC | J.Bradley (5), B.Thomas (6), E.Marzilli (1), K.Enders (1) |
| 05/05 | #4 South Carolina 14, Winthrop 6 | J.Mata (W, 5-0) | | Columbia, SC | | W.Merrifield 2(10), J.Bradley 2(7), C.Walker (5), J.Jones (7), B.Haney (1) |
| 05/07 | #4 South Carolina 13, Kentucky 9 | B.Cooper (W, 9-0) | M.Price (5) | Lexington, KY | SEC | |
| 05/08 | Kentucky 2, #4 South Carolina 1 | S.Dyson (L, 4-4) | | Lexington, KY | SEC | E.Marzilli (2) |
| 05/09 | Kentucky 9, #4 South Carolina 3 | J.Mata (L, 5-1) | | Lexington, KY | SEC | |
| 05/11 | #7 South Carolina 17, Wofford 4 | N.Belcher (W, 3-0) | | Columbia, SC | | J.Bradley (8), N.Ebert (5) |
| 05/12 | #7 South Carolina 10, Charleston Southern 2 | J.Mata (W, 6-1) | | Columbia, SC | | C.Walker (6), N.Ebert (6), A.Matthews (5), B.Haney (2) |
| 05/14 | South Carolina 3, Arkansas 2 | B.Cooper (W, 10-0) | M.Price (6) | Fayetteville, AR | SEC | |
| 05/15 | #7 South Carolina 5, #10 Arkansas 0 | S.Dyson (W, 5-4) | | Fayetteville, AR | SEC | B.Thomas (7) |
| 05/16 | #7 South Carolina 5, #10 Arkansas 3 | J.Taylor (W, 3-2) | M.Price (7) | Fayetteville, AR | SEC | W.Merrifield 2(12), A.Morales (5) |
| 05/18 | #6 South Carolina 11, Furman 6 | S.Neff (W, 2-1) | | Columbia, SC | | B.Haney (3) |
| 05/20 | #6 South Carolina 3, #4 Florida 2 | B.Cooper (L, 10-1) | | Columbia, SC | SEC | J.Jones (8) |
| 05/21 | #4 Florida 5, #6 South Carolina 2 | S.Dyson (L, 5-5) | | Columbia, SC | SEC | A.Matthews (6) |
| 05/22 | #6 South Carolina 11, #4 Florida 6 | J.Brown (W, 3-0) | | Columbia, SC | SEC | J.Bradley (9), A.Matthews (7), N.Ebert (7) |
| 05/26 | Mississippi 3, South Carolina 0 | N.Belcher (L, 3-1) | | Hoover, AL | SEC Tournament | |
| 05/27 | Auburn 3, South Carolina 1 | M.Price (L, 3-1) | | Hoover, AL | SEC Tournament | B.Thomas (8) |
| 06/04 | South Carolina 9, Bucknell 5 | M.Roth (W, 1-1) | | Columbia, SC | NCAA Regional | E.Marzilli (3), J.Bradley (10), A.Morales (6) |
| 06/05 | South Carolina 9, Citadel 4 | B.Cooper (W, 11-1) | M.Price (8) | Columbia, SC | NCAA Regional | A.Morales (7), K.Enders (2) |
| 06/06 | South Carolina 10, Virginia Tech 2 | J.Mata (W, 7-1) | | Columbia, SC | NCAA Regional | J.Bradley (11), A.Morales (8) |
| 06/12 | South Carolina 4, Coastal Carolina 3 | B.Cooper (W, 12-1) | M.Price (9) | Myrtle Beach, SC | NCAA Super Regional | |
| 06/13 | South Carolina 10, Coastal Carolina 9 | E.Carter (W, 3-0) | M.Price (10) | Myrtle Beach, SC | NCAA Super Regional | C.Walker (7) |
| 06/20 | Oklahoma 4, South Carolina 3 | B.Cooper (L, 12-2) | | Omaha, NE | College World Series | J.Bradley (12), C.Walker (8) |
| 06/22 | South Carolina 11, Arizona State 4 | S.Dyson (W, 6-5) | | Omaha, NE | College World Series | W.Merrfield (13), J.Bradley (13), A.Morales (9) |
| 06/24 | South Carolina 3, Oklahoma 2 | T.Webb (W, 3-2) | | Omaha, NE | College World Series | |
| 06/25 | South Carolina 5, Clemson 1 | M.Roth (W, 2-1) | | Omaha, NE | College World Series | K.Enders (3) |
| 06/26 | South Carolina 4, Clemson 3 | M.Price (W, 4-1) | | Omaha, NE | College World Series | C.Walker (9) |
| 06/28 | South Carolina 7, UCLA 1 | B.Cooper (W, 13-2) | | Omaha, NE | College World Series | |
| 06/29 | South Carolina 2, UCLA 1 | M.Price (W, 5-1) | | Omaha, NE | College World Series | |