| 2016 Results | | Date | Result | SC W/L | SC Save | Location | Game Type | SC HR |
| 02/19 | South Carolina 10, Albany 1 | C.Schmidt (W, 1-0) | | Columbia, SC | | D.Thompson-Williams (1) |
| 02/20 | South Carolina 6, Albany 2 | B.Webb (W, 1-0) | J.Reagan (1) | Columbia, SC | | J.Jones (1) |
| 02/21 | South Carolina 8, Albany 1 | C.Bowers (W, 1-0) | | Columbia, SC | | |
| 02/23 | South Carolina 5, Appalachian State 0 | A.Hill (W, 1-0) | | Columbia, SC | | |
| 02/24 | South Carolina 16, Winthrop 4 | T.Haswell (W, 1-0) | | Columbia, SC | | T.Hopkins (1) |
| 02/26 | South Carolina 7, Penn State 1 | C.Schmidt (W, 2-0) | | Columbia, SC | | J.Jones (2) |
| 02/27 | South Carolina 16, Penn State 5 | B.Webb (W, 2-0) | | Columbia, SC | | J.Jones (3), A.Destino 2 (2) |
| 02/28 | South Carolina 4, Penn State 2 | R.Scott (W, 1-0) | J.Reagan (2) | Columbia, SC | | |
| 03/01 | South Carolina 6, Citadel 3 | A.Hill (W, 2-0) | J.Reagan (3) | Charleston, SC | | |
| 03/04 | South Carolina 8, Clemson 1 | C.Schmidt (W, 3-0) | | Columbia, SC | | |
| 03/05 | Clemson 5, South Carolina 0 | B.Webb (L, 2-1) | | Greenville, SC | | |
| 03/06 | Clemson 4, South Carolina 1 | T.Widener (L, 0-1) | | Clemson, SC | | |
| 03/08 | South Carolina 7, Wofford 1 | A.Hill (W, 3-0) | | Columbia, SC | | D.Thompson-Williams (2) |
| 03/09 | South Carolina 5, Furman 4 | T.Haswell (W, 2-0) | J.Reagan (4) | Columbia, SC | | J.Jones (4), A.Destino (3) |
| 03/11 | South Carolina 9, Charleston Southern 0 | C.Schmidt (W, 4-0) | | Columbia, SC | | D.Thompson-Williams (3) |
| 03/12 | South Carolina 5, Charleston Southern 4 | B.Webb (W, 3-1) | J.Reagan (5) | Columbia, SC | | A.Destino (4), D.Thompson-Williams (4) |
| 03/13 | South Carolina 2, Charleston Southern 0 | A.Hill (W, 4-0) | J.Reagan (6) | Columbia, SC | | M.Williams (1) |
| 03/15 | South Carolina 12, USC-Upstate 6 | B.Murray (W, 1-0) | | Greenville, SC | | L.Tolbert (1), M.Mooney (1) |
| 03/16 | South Carolina 15, Davidson 2 | M.Vogel (W, 1-0) | | Columbia, SC | | |
| 03/18 | South Carolina 10, Arkansas 6 | C.Schmidt (W, 5-0) | | Columbia, SC | SEC | |
| 03/19 | South Carolina 6, Arkansas 2 | B.Webb (W, 4-1) | T.Johnson (1) | Columbia, SC | SEC | J.Jones (5) |
| 03/20 | South Carolina 8, Arkansas 6 | J.Reagan (W, 1-0) | | Columbia, SC | SEC | J.Jones (6) |
| 03/24 | South Carolina 5, Mississippi 1 | C.Schmidt (W, 6-0) | J.Reagan (7) | Oxford, MS | SEC | G.Cone (1) |
| 03/25 | South Carolina 9, Mississippi 5 | B.Webb (W, 5-1) | | Oxford, MS | SEC | |
| 03/26 | South Carolina 4, Mississippi 0 | A.Hill (W, 5-0) | T.Johnson (2) | Oxford, MS | SEC | |
| 03/29 | College of Charleston 6, South Carolina 5 | R.Scott (L, 1-1) | | Columbia, SC | | |
| 03/31 | Vanderbilt 6, South Carolina 3 | C.Schmidt (L, 6-1) | | Nashville, TN | SEC | |
| 04/01 | South Carolina 4, Vanderbilt 0 | B.Webb (W, 6-1) | | Nashville, TN | SEC | |
| 04/02 | Vanderbilt 10, South Carolina 6 | T.Johnson (L, 0-1) | | Nashville, TN | SEC | J.Bride (1), D.Arendas (2) |
| 04/05 | South Carolina 4, Coastal Carolina 2 | T.Widener (W, 1-1) | J.Reagan (8) | Columbia, SC | | |
| 04/08 | South Carolina 7, Tennessee 6 | C.Schmidt (W, 7-1) | J.Reagan (9) | Columbia, SC | SEC | L.Tolbert (2) |
| 04/09 | South Carolina 7, Tennessee 4 | B.Webb (W, 7-1) | R.Scott (1) | Columbia, SC | SEC | |
| 04/10 | South Carolina 4, Tennessee 3 | T.Johnson (W, 1-1) | J.Reagan (10) | Columbia, SC | SEC | |
| 04/13 | North Carolina 15, South Carolina 0 | T.Widener (L, 1-2) | | Charlotte, NC | | |
| 04/15 | South Carolina 3, Georgia 1 | C.Schmidt (W, 8-1) | | Athens, GA | SEC | |
| 04/16 | Georgia 13, South Carolina 4 | B.Webb (L, 7-2) | | Athens, GA | SEC | G.Cone (2) |
| 04/17 | Georgia 5, South Carolina 3 | J.Reagan (L, 1-1) | | Athens, GA | SEC | |
| 04/20 | South Carolina 14, Furman 4 | R.Scott (W, 2-1) | | Greenville, SC | | |
| 04/22 | South Carolina 8, Missouri 5 | R.Scott (W, 3-1) | T.Johnson (3) | Columbia, SC | SEC | |
| 04/23 | South Carolina 5, Missouri 1 | B.Webb (W, 8-2) | J.Reagan (11) | Columbia, SC | SEC | |
| 04/24 | South Carolina 9, Missouri 2 | A.Hill (W, 6-0) | | Columbia, SC | SEC | |
| 04/29 | #1 Florida 5, #2 South Carolina 4 | J.Reagan (L, 1-2) | | Columbia, SC | SEC | A.Destino (5), C.Cullen (1) |
| 04/30 | #2 South Carolina 2, #1 Florida 1 | B.Webb (W, 9-2) | T.Johnson (4) | Columbia, SC | SEC | G.Cone (3) |
| 05/04 | #2 South Carolina 4, USC-Upstate 1 | T.Widener (W, 2-2) | T.Johnson (5) | Columbia, SC | | |
| 05/06 | #2 South Carolina 10, Kentucky 5 | C.Schmidt (W, 9-1) | | Lexington, KY | SEC | A.Destino (6), L.Tolbert (3) |
| 05/07 | Kentucky 6, #2 South Carolina 0 | B.Webb (L, 9-3) | | Lexington, KY | SEC | |
| 05/08 | Kentucky 5, #2 South Carolina 4 | T.Johnson (L, 1-2) | | Lexington, KY | SEC | J.Bride (2) |
| 05/10 | #3 South Carolina 3, Presbyterian 1 | T.Widener (W, 3-2) | R.Scott (2) | Columbia, SC | | A.Destino 2(8) |
| 05/13 | #2 Texas A&M 3, #8 South Carolina 0 | C.Schmidt (L, 9-2) | | Columbia, SC | SEC | |
| 05/14 | #2 Texas A&M 5, #8 South Carolina 2 | B,Webb (L, 9-4) | | Columbia, SC | SEC | M.Stokes (1) |
| 05/15 | #8 South Carolina 10, #2 Texas A&M 7 | J.Reagan (W, 2-2) | T.Johnson (6) | Columbia, SC | SEC | D.Thompson-Williams 2(6) |
| 05/17 | #6 South Carolina 16, Citadel 4 | B.Murray (W, 2-0) | | Columbia, SC | | D.Arendas (3) |
| 05/19 | #6 South Carolina 6, Alabama 4 | R.Scott (W, 4-1) | T.Johnson (7) | Tuscaloosa, AL | SEC | |
| 05/20 | #6 South Carolina 4, Alabama 2 | B.Webb (W, 10-4) | T.Johnson (8) | Tuscaloosa, AL | SEC | D.Thompson-Williams (7), J.Jones (7) |
| 05/21 | #6 South Carolina 9, Alabama 7 | T.Widener (W, 4-2) | T.Johnson (9) | Tuscaloosa, AL | SEC | |
| 05/25 | Mississippi 10, South Carolina 4 | C.Schmidt (L, 9-3) | | Hoover, AL | SEC Tournament | |
| 05/26 | Texas A&M 4, South Carolina 1 | B.Webb (L, 10-5) | | Hoover, AL | SEC Tournament | |
| 06/03 | Rhode Island 5, South Carolina 4 | C.Schmidt (L, 9-4) | | Columbia, SC | NCAA Regional | G.Cone (4), A.Destino (9) |
| 06/04 | South Carolina 4, Duke 2 | T.Johnson (W, 2-2) | | Columbia, SC | NCAA Regional | |
| 06/05 | South Carolina 23, Rhode Island 2 | A.Hill (W, 7-0) | | Columbia, SC | NCAA Regional | A.Destino (10), D.Arendas (4), M.Williams (2) |
| 06/05 | South Carolina 10, UNC-Wilmington 1 | T.Johnson (W, 3-2) | | Columbia, SC | NCAA Regional | |
| 06/07 | South Carolina 10, UNC-Wilmington 5 | J.Reagan (W, 3-2) | | Columbia, SC | NCAA Regional | D.Arendas (5) |
| 06/11 | Oklahoma State 5, South Carolina 1 | B.Webb (L, 10-6) | | Columbia, SC | NCAA Super Regional | D.Thompson-Williams (8) |
| 06/12 | Oklahoma State 3, South Carolina 1 | C.Schmidt (L, 9-5) | | Columbia, SC | NCAA Super Regional | |