| 1921-22 Results | | Date | Result | Site | Game Type | High Scorer | Summary |
1922-01-12 | North Carolina 44, South Carolina 28 | Chapel Hill, NC | | | | 1922-01-13 | Trinity College 41, South Carolina 25 | Durham, NC | | | | 1922-01-14 | N.C. State 19, South Carolina 14 | Raleigh, NC | | | | 1922-01-16 | Richmond 27, South Carolina 25 | Richmond, VA | | | | 1922-01-19 | Lynchburg Elks 50, South Carolina 7 | Lynchburg, VA | | | | 1922-02-01 | Newberry 33, South Carolina 27 | Columbia, SC | | | | 1922-02-04 | Georgia 36, South Carolina 27 | Columbia, SC | | | | 1922-02-06 | South Carolina 30, Furman 23 | Columbia, SC | | | | 1922-02-09 | South Carolina 35, Presbyterian 9 | Columbia, SC | | | | 1922-02-11 | South Carolina 22, Wofford 20 | Columbia, SC | | | | 1922-02-13 | South Carolina 18, Citadel 17 | Columbia, SC | | | | 1922-02-15 | Newberry 34, South Carolina 27 | Newberry, SC | | | | 1922-02-16 | South Carolina 37, Wofford 17 | Spartanburg, SC | | | | 1922-02-17 | Furman 27, South Carolina 24 | Greenville, SC | | | | 1922-02-18 | South Carolina 32, Presbyterian 13 | Clinton, SC | | | | 1922-02-24 | South Carolina 34, Wofford 18 | Atlanta, GA | SIAA Tournament | | | 1922-02-25 | Georgia Tech 34, South Carolina 23 | Atlanta, GA | SIAA Tournament | | | 1922-03-03 | West End Athletic Club 35, South Carolina 29 | Charleston, SC | | | | 1922-03-04 | Citadel 29, South Carolina 16 | Charleston, SC | | | |