| 1980-81 Results | | Date | Result | Site | Game Type | High Scorer | Summary |
1980-11-28 | Western Kentucky 73, South Carolina 69 | Bowling Green, KY | Wendy's Classic | | | 1980-11-29 | Iona 79, South Carolina 69 | Bowling Green, KY | Wendy's Classic | | | 1980-12-01 | Marshall 116, South Carolina 85 | Huntington, WV | | | | 1980-12-03 | South Carolina 85, UNC-Asheville 57 | Columbia, SC | | | | 1980-12-06 | Clemson 82, South Carolina 69 | Columbia, SC | | | | 1980-12-12 | South Carolina 80, Biscayne 60 | Columbia, SC | | | | 1980-12-19 | South Carolina 83, Citadel 81 | Columbia, SC | Palmetto Classic | | | 1980-12-20 | South Carolina 62, Furman 53 | Columbia, SC | Palmetto Classic | | | 1980-12-23 | South Carolina 74, Texas 70 | Columbia, SC | | | | 1980-12-31 | South Carolina 80, Florida State 78 | Miami, FL | | | | 1981-01-03 | South Carolina 72, East Tennessee State 68 | Johnson City, TN | | | | 1981-01-05 | Cleveland State 82, South Carolina 76 | Columbia, SC | | | | 1981-01-10 | Rhode Island 94, South Carolina 84 | Providence, RI | | | | 1981-01-15 | South Carolina 90, Manhattan 62 | Columbia, SC | | | | 1981-01-17 | South Carolina 91, Marquette 89 | Milwaukee, WI | | | | 1981-01-21 | Temple 68, South Carolina 64 | Columbia, SC | | | | 1981-01-24 | South Carolina 103, Davidson 88 | Columbia, SC | | | | 1981-01-26 | South Carolina 93, Richmond 77 | Columbia, SC | | | | 1981-01-28 | South Carolina 90, Hofstra 72 | Columbia, SC | | | | 1981-01-31 | Notre Dame 94, South Carolina 84 | South Bend, IN | | | | 1981-02-04 | South Carolina 70, Penn State 60 | Columbia, SC | | | | 1981-02-08 | Clemson 115, South Carolina 91 | Clemson, SC | | | | 1981-02-11 | South Carolina 87, Furman 74 | Columbia, SC | | | | 1981-02-14 | William & Mary 77, South Carolina 68 | Williamsburg, VA | | | | 1981-02-18 | South Carolina 83, Florida State 70 | Columbia, SC | | | | 1981-02-21 | South Carolina 93, Boston U. 86 | Boston, MA | | | | 1981-02-23 | South Carolina 106, Georgia Southern 69 | Columbia, SC | | | |