| Players | |||||
|---|---|---|---|---|---|
| Name | Pos | Begin | End | City | State |
| Matt O'Brien | FS | 2010 | 2011 | New Milford | NJ |
| Paul O'Cain | G | 1959 | 1959 | Orangeburg | SC |
| G.B. O'Connell | B | 1943 | 1943 | Highland Park | IL |
| Tom O'Connor | P | 1984 | 1985 | East Patchogue | NY |
| Firpo O'Dell | 1932 | 1932 | Larry O'Hagan | DE | 1976 | 1976 | Augusta | GA | Bob O'Harra | RB | 1969 | 1970 | Florence | SC | Bobby O'Harra | E | 1942 | 1947 | Florence | SC | Sean Odom | WR | 2014 | 2015 | Orangeburg | SC | Paul Odomirok | C | 1972 | 1975 | Hollywood | FL |
| Andre Offing | LB | 1996 | 2000 | Houston | TX |
| Willie Offord | SS | 1997 | 2001 | Palatka | FL |
| Marvin Oglesby | LB | 1987 | 1987 | Decatur | GA |
| R.C. Oglesby | HB | 1911 | 1912 | Cowpens | SC |
| Matt Oliveira | DS | 2019 | 2019 | Watchung | NJ | Gene Oliver | LH | 1900 | 1903 | Len Oliver | WR | 1978 | 1979 | Charlotte | NC | Tommy Oliver | OG | 1976 | 1977 | Atlanta | GA | Walter Ollic | QB | 1954 | 1955 | Charleston | SC | Ben Olszewski | E | 1964 | 1964 |
| Bob Orkis | LB | 1976 | 1978 | Gahanna | OH |
| Chris Orr | DB | 1994 | 1995 | Estill | SC |
| John Orr | B | 1970 | 1970 | Hendersonville | NC |
| Wally Orrel | DB | 1966 | 1968 | Savannah | GA |
| Perry Orth | QB | 2013 | 2016 | Ponte Vedra | FL | Rut Osborne | B | 1941 | 1941 | Orangeburg | SC | Rut L. Osborne | 1915 | 1917 | Larry Otto | LB | 1973 | 1973 | Raleigh | NC | Jazuun Outlaw | DE | 2017 | 2019 | Dillon | SC | Anthony Overstreet | DT | 1996 | 2000 | Atlanta | GA |
| Charlie Overstreet | G | 1961 | 1961 | North Augusta | SC |
| Allen Owen | DE | 1967 | 1967 | Columbus | GA |
| Calvin Owens | WR | 1994 | 1997 | North Augusta | SC |
| Christian Owens | WR | 2015 | 2015 | Griffin | GA |
| Drew Owens | TE | 2011 | 2014 | Charlotte | NC | Harold Owens | E | 1948 | 1948 | Sumter | SC | John (Red) Ozburn | T | 1946 | 1948 | Andrews | SC |