| Gamecock Softball Opponents | ||||
|---|---|---|---|---|
| Opponent | Wins | Losses | First Game | Last Game |
| Adelphi | 9 | 3 | 1980 | 1989 |
| Akron | 1 | 0 | 1989 | 1989 |
| Alabama | 6 | 33 | 2005 | 2019 |
| Alabama State | 1 | 0 | 2013 | 2013 |
| Allen | 1 | 0 | 1977 | 1977 | American | 1 | 0 | 1982 | 1982 | Appalachian State | 3 | 0 | 2012 | 2015 | Arizona | 2 | 4 | 1983 | 2017 | Arizona State | 3 | 6 | 1983 | 2018 | Arkansas | 24 | 13 | 2005 | 2019 |
| Auburn | 12 | 28 | 2005 | 2019 |
| Austin Peay | 1 | 0 | 1989 | 1989 |
| Ball State | 1 | 2 | 1982 | 2019 |
| Barrington | 3 | 0 | 1976 | 1977 |
| Baylor | 3 | 1 | 1985 | 2019 | Benedict | 3 | 0 | 1977 | 1979 | Bethune-Cookman | 1 | 1 | 2006 | 2019 | Bloomsburg | 1 | 2 | 1982 | 1984 | Boston College | 3 | 0 | 1986 | 2020 | Boston U. | 2 | 0 | 2005 | 2014 |
| Bowling Green | 3 | 1 | 1983 | 2009 |
| Bradley | 3 | 0 | 1987 | 2018 |
| Brigham Young | 1 | 0 | 2019 | 2019 |
| Brown | 3 | 0 | 1981 | 1981 |
| Bryant | 2 | 0 | 2019 | 2019 | Bucknell | 2 | 0 | 2008 | 2008 | Buffalo | 3 | 0 | 2013 | 2016 | Cal Poly | 1 | 0 | 2008 | 2008 | Cal State-Fullerton | 0 | 4 | 1983 | 1987 | Cal State-Northridge | 1 | 0 | 2008 | 2008 |
| Cal-Davis | 1 | 0 | 2012 | 2012 |
| Cal-Riverside | 1 | 0 | 2012 | 2012 |
| Cal-Santa Barbara | 2 | 0 | 2016 | 2016 |
| California | 1 | 1 | 1986 | 2015 |
| Campbell | 5 | 1 | 2007 | 2019 | Canadian Comets | 2 | 0 | 1979 | 1979 | Canisius | 1 | 0 | 2006 | 2006 | Central Florida | 0 | 5 | 2010 | 2015 | Central Michigan | 5 | 3 | 1983 | 1989 | Charleston Southern | 16 | 1 | 1988 | 2019 |
| Charlotte | 24 | 5 | 1988 | 2020 |
| Chattanooga | 1 | 0 | 2009 | 2009 |
| Claflin | 3 | 0 | 1975 | 1976 |
| Clemson | 1 | 0 | 1979 | 1979 |
| Cleveland State | 1 | 0 | 2012 | 2012 | Coastal Carolina | 24 | 7 | 1989 | 2020 | Coker | 4 | 0 | 1975 | 1977 | Colgate | 1 | 0 | 1987 | 1987 | College of Charleston | 10 | 1 | 2006 | 2017 | College of New Jersey | 3 | 1 | 1978 | 1982 |
| Columbia Amateurs | 2 | 0 | 2006 | 2006 |
| Connecticut | 3 | 0 | 1985 | 2016 |
| Cortland | 5 | 0 | 1980 | 1982 |
| Creighton | 1 | 3 | 1982 | 1990 |
| Dartmouth | 1 | 0 | 2015 | 2015 | Delaware | 1 | 0 | 1981 | 1981 | Delaware State | 1 | 0 | 2015 | 2015 | Delta State | 1 | 2 | 1975 | 1976 | DePaul | 1 | 1 | 2010 | 2010 | Detroit | 1 | 0 | 1987 | 1987 |
| Duke | 3 | 0 | 2018 | 2019 |
| East Carolina | 11 | 3 | 1985 | 2015 |
| East Stroudsburg | 2 | 3 | 1976 | 1980 |
| East Tennessee State | 1 | 0 | 2007 | 2007 |
| Eastern Illinois | 3 | 1 | 1985 | 2009 | Eastern Kentucky | 2 | 0 | 2006 | 2014 | Eastern Michigan | 3 | 2 | 1982 | 1989 | Elon | 2 | 1 | 2011 | 2020 | Erskine | 6 | 1 | 1976 | 1978 | Evansville | 1 | 0 | 1986 | 1986 |
| Fairleigh Dickinson | 3 | 0 | 1978 | 1981 |
| Florida | 1 | 36 | 2005 | 2019 |
| Florida A&M | 1 | 1 | 2010 | 2013 |
| Florida Atlantic | 4 | 2 | 2006 | 2014 |
| Florida Gulf Coast | 1 | 0 | 2011 | 2011 | Florida International | 2 | 2 | 2012 | 2018 | Florida State | 13 | 12 | 1985 | 2019 | Fordham | 1 | 1 | 2006 | 2014 | Francis Marion | 9 | 0 | 1981 | 1984 | Frost Mill | 0 | 1 | 1984 | 1984 |
| Furman | 35 | 5 | 1976 | 2019 |
| Gardner-Webb | 5 | 0 | 2005 | 2017 |
| George Mason | 5 | 1 | 1984 | 1987 |
| George Washington | 2 | 0 | 2012 | 2018 |
| Georgetown | 2 | 0 | 2011 | 2018 | Georgia | 11 | 29 | 2005 | 2020 | Georgia Southern | 14 | 1 | 1988 | 2020 | Georgia State | 13 | 0 | 1986 | 2019 | Georgia Tech | 3 | 0 | 2005 | 2016 | Greensboro | 7 | 0 | 2005 | 2020 |
| Hofstra | 3 | 1 | 2008 | 2018 |
| Houston | 3 | 0 | 2009 | 2013 |
| Illinois State | 5 | 3 | 1983 | 2018 |
| Illinois-Chicago | 1 | 0 | 2012 | 2012 |
| Indiana | 5 | 10 | 1977 | 2018 | Indiana State | 4 | 0 | 1982 | 1986 | Iowa | 2 | 0 | 1983 | 2014 | Iowa State | 2 | 1 | 2006 | 2020 | Ithaca | 7 | 2 | 1980 | 1983 | Jacksonville | 1 | 1 | 2007 | 2012 |
| Jacksonville State | 1 | 0 | 2007 | 2007 |
| Kansas | 3 | 2 | 1986 | 2020 |
| Kansas State | 1 | 0 | 1985 | 1985 |
| Kennesaw State | 3 | 0 | 2013 | 2016 |
| Kent State | 1 | 0 | 1988 | 1988 | Kentucky | 16 | 24 | 2005 | 2019 | Kilgore Tomboys | 3 | 0 | 1978 | 1978 | Kutztown | 2 | 0 | 1981 | 1982 | Lehigh | 1 | 0 | 2018 | 2018 | Liberty | 4 | 0 | 2015 | 2018 |
| Limestone | 2 | 0 | 1977 | 1978 |
| Long Beach State | 1 | 1 | 1987 | 2017 |
| Long Island | 2 | 0 | 2014 | 2015 |
| Longwood | 9 | 3 | 2010 | 2017 |
| Louisiana Tech | 5 | 20 | 1983 | 2017 | Louisiana-Lafayette | 1 | 3 | 1986 | 1990 | Louisiana-Monroe | 3 | 0 | 1985 | 1990 | Louisville | 1 | 0 | 2018 | 2018 | Loyola (IL) | 1 | 0 | 2010 | 2010 | LSU | 12 | 31 | 1982 | 2019 |
| Macomb Community College | 1 | 0 | 1981 | 1981 |
| Maine | 3 | 0 | 1987 | 2012 |
| Marshall | 3 | 0 | 2015 | 2018 |
| Maryland | 1 | 1 | 2014 | 2014 |
| Massachusetts | 7 | 2 | 1980 | 2013 | McNeese State | 1 | 0 | 1988 | 1988 | Memphis | 1 | 1 | 2006 | 2007 | Mercer | 3 | 0 | 2005 | 2018 | Miami (Ohio) | 6 | 0 | 1980 | 2018 | Michigan | 4 | 6 | 1982 | 2020 |
| Michigan State | 6 | 2 | 1982 | 2018 |
| Middle Tennessee State | 1 | 0 | 2019 | 2019 |
| Minnesota | 1 | 2 | 1988 | 2014 |
| Mississippi | 19 | 17 | 2005 | 2019 |
| Mississippi College | 3 | 0 | 1975 | 1976 | Mississippi State | 16 | 22 | 1985 | 2018 | Mississippi University for Women | 1 | 0 | 1976 | 1976 | Missouri | 6 | 10 | 2013 | 2019 | Missouri State | 1 | 2 | 1980 | 1990 | Montclair State | 1 | 0 | 1980 | 1980 |
| N.C. Central | 1 | 0 | 2020 | 2020 |
| N.C. State | 3 | 1 | 2006 | 2011 |
| Nebraska | 0 | 1 | 1986 | 1986 |
| New Mexico | 1 | 0 | 1984 | 1984 |
| Nicholls State | 7 | 4 | 1983 | 1990 | North Carolina | 24 | 6 | 1985 | 2019 | North Dakota State | 4 | 0 | 2006 | 2020 | North Florida | 5 | 1 | 2007 | 2010 | North Texas | 2 | 1 | 1980 | 1981 | Northern Illinois | 4 | 1 | 1979 | 1986 |
| Northern Iowa | 1 | 0 | 1981 | 1981 |
| Northern Oklahoma | 1 | 0 | 1976 | 1976 |
| Northwestern | 5 | 6 | 1980 | 2017 |
| Northwestern State | 1 | 1 | 1990 | 1990 |
| Notre Dame | 1 | 0 | 2019 | 2019 | Ohio | 7 | 1 | 14 | 2019 | Ohio State | 1 | 1 | 2005 | 2020 | Oklahoma | 1 | 3 | 1983 | 2018 | Oklahoma City | 4 | 0 | 1981 | 1990 | Oklahoma State | 2 | 2 | 1983 | 1988 |
| Onondaga Community College | 2 | 0 | 1979 | 1979 |
| Oregon | 2 | 3 | 1989 | 2008 |
| Oregon State | 0 | 1 | 1979 | 1979 |
| Orlando Rebels | 5 | 6 | 1981 | 1981 |
| Orlando Suns | 4 | 0 | 1979 | 1979 | Pacific | 1 | 0 | 1983 | 1983 | Penn State | 7 | 1 | 1981 | 2013 | Pittsburgh | 4 | 0 | 2006 | 2007 | Portland State | 1 | 1 | 1978 | 2012 | Prentiss Institute | 1 | 0 | 1975 | 1975 |
| Presbyterian | 7 | 0 | 2012 | 2017 |
| Princeton | 4 | 0 | 1986 | 2006 |
| Providence | 3 | 1 | 2010 | 2012 |
| Purdue | 1 | 0 | 2006 | 2006 |
| Radford | 2 | 0 | 2007 | 2013 | Rhode Island | 8 | 1 | 1981 | 1987 | Rider | 1 | 0 | 1983 | 1983 | Rowan | 2 | 1 | 1979 | 1980 | Rutgers | 8 | 4 | 1976 | 1987 | S.C. State | 1 | 0 | 2014 | 2014 |
| Sam Houston State | 4 | 3 | 1980 | 1990 |
| Seton Hall | 3 | 0 | 1982 | 2011 |
| South Alabama | 1 | 1 | 2015 | 2018 |
| South Dakota State | 1 | 0 | 2005 | 2005 |
| South Florida | 14 | 8 | 1985 | 2019 | Southeastern Louisiana | 2 | 0 | 2005 | 2005 | Southern Illinois | 3 | 0 | 2005 | 2020 | Southern Illinois-Edwardsville | 1 | 0 | 2016 | 2016 | Southern Mississippi | 2 | 0 | 1975 | 1990 | Southern Utah | 2 | 0 | 2016 | 2016 |
| Southern Wesleyan | 1 | 0 | 1978 | 1978 |
| St. Francis | 2 | 0 | 2017 | 2017 |
| St. John's | 2 | 0 | 2018 | 2019 |
| St. Mary's | 1 | 1 | 1986 | 1990 |
| Stanford | 1 | 0 | 2015 | 2015 | Stephen F. Austin | 1 | 0 | 2005 | 2005 | Stetson | 5 | 0 | 1987 | 2013 | Syracuse | 0 | 2 | 2005 | 2005 | Temple | 1 | 0 | 1987 | 1987 | Tennessee | 6 | 27 | 2005 | 2018 |
| Tennessee State | 1 | 1 | 2012 | 2015 |
| Texas | 2 | 3 | 1979 | 2018 |
| Texas A&M | 9 | 16 | 1981 | 2018 |
| Texas State | 1 | 0 | 1990 | 1990 |
| Texas Tech | 0 | 1 | 2020 | 2020 | Texas Wesleyan | 1 | 0 | 1980 | 1980 | Texas-Arlington | 4 | 3 | 1980 | 2013 | Toledo | 4 | 0 | 1985 | 1989 | Towson | 1 | 0 | 1981 | 1981 | Troy | 5 | 2 | 2009 | 2020 |
| Truman State | 1 | 0 | 1983 | 1983 |
| U.S. International | 0 | 1 | 1987 | 1987 |
| UCLA | 0 | 5 | 1981 | 2017 |
| UNC-Wilmington | 6 | 0 | 1990 | 2016 |
| USC-Upstate | 7 | 3 | 2009 | 2019 | Utah | 3 | 3 | 1984 | 1988 | Utah State | 0 | 4 | 1978 | 1987 | Villanova | 5 | 2 | 1983 | 2013 | Virginia | 12 | 0 | 1980 | 1990 | Virginia Tech | 3 | 6 | 2005 | 2020 |
| Voorhees | 2 | 0 | 1976 | 1976 |
| Washington | 0 | 1 | 2020 | 2020 |
| Wayne State | 1 | 3 | 1983 | 1984 |
| West Chester | 1 | 0 | 1982 | 1982 |
| West Virginia | 2 | 0 | 1980 | 1982 | Western Carolina | 6 | 0 | 2007 | 2016 | Western Illinois | 3 | 0 | 1983 | 1990 | Western Kentucky | 2 | 0 | 2012 | 2015 | Western Michigan | 3 | 3 | 1981 | 2019 | Winthrop | 37 | 8 | 1975 | 2020 |
| Wisconsin | 2 | 0 | 2005 | 2008 |
| Wright State | 1 | 0 | 2008 | 2008 |
| Youngstown State | 1 | 0 | 2019 | 2019 |