| 2010 Results | | Date | Result | SC W/L | SC Save | Location | Game Type | SC HR |
| 02/14 | South Carolina 11, Coastal Carolina 3 | | | Columbia, SC | | |
| 02/14 | South Carolina 6, Winthrop 4 | | | Columbia, SC | | |
| 02/16 | South Carolina 5, Longwood 1 | | | Columbia, SC | | |
| 02/16 | South Carolina 9, Longwood 2 | | | Columbia, SC | | |
| 02/19 | South Carolina 4, Florida A&M 2 | | | Orlando, FL | UCF Invitational | |
| 02/19 | Central Florida 4, South Carolina 1 | | | Orlando, FL | UCF Invitational | |
| 02/20 | Villanova 3, South Carolina 0 | | | Orlando, FL | UCF Invitational | |
| 02/20 | South Carolina 9, North Florida 0 | | | Orlando, FL | UCF Invitational | |
| 02/21 | Troy 5, South Carolina 4 | | | Orlando, FL | UCF Invitational | |
| 02/23 | Charlotte 8, South Carolina 1 | | | Columbia, SC | | |
| 02/27 | South Carolina 1, Providence 0 | | | Boca Raton, FL | FAU Strike Out Cancer Tournament | |
| 02/27 | South Carolina 15, Loyola (IL) 1 | | | Boca Raton, FL | FAU Strike Out Cancer Tournament | |
| 02/28 | Providence 4, South Carolina 3 | | | Boca Raton, FL | FAU Strike Out Cancer Tournament | |
| 02/28 | Florida Atlantic 1, South Carolina 0 | | | Boca Raton, FL | FAU Strike Out Cancer Tournament | |
| 03/05 | DePaul 6, South Carolina 0 | | | Tuscaloosa, AL | Easton SEC/Midwest Challenge | |
| 03/06 | #7 Michigan 1, South Carolina 0 | | | Tuscaloosa, AL | Easton SEC/Midwest Challenge | |
| 03/06 | South Carolina 1, DePaul 0 | | | Tuscaloosa, AL | Easton SEC/Midwest Challenge | |
| 03/07 | #7 Michigan 8, South Carolina 0 | | | Tuscaloosa, AL | Easton SEC/Midwest Challenge | |
| 03/10 | Mississippi 3, South Carolina 0 | | | Oxford, MS | SEC | |
| 03/10 | Mississippi 6, South Carolina 3 | | | Oxford, MS | SEC | |
| 03/13 | #14 LSU 5, South Carolina 0 | | | Columbia, SC | SEC | |
| 03/13 | #14 LSU 9, South Carolina 0 | | | Columbia, SC | SEC | |
| 03/14 | #14 LSU 10, South Carolina 0 | | | Columbia, SC | SEC | |
| 03/17 | Arkansas 8, South Carolina 5 | | | Columbia, SC | SEC | |
| 03/17 | Arkansas 3, South Carolina 2 | | | Columbia, SC | SEC | |
| 03/20 | #8 Alabama 8, South Carolina 0 | | | Tuscaloosa, AL | SEC | |
| 03/20 | #8 Alabama 8, South Carolina 2 | | | Tuscaloosa, AL | SEC | |
| 03/21 | #8 Alabama 21, South Carolina 1 | | | Tuscaloosa, AL | SEC | |
| 03/24 | South Carolina 3, Coastal Carolina 1 | | | Conway, SC | | |
| 03/27 | Auburn 4, South Carolina 1 | | | Columbia, SC | SEC | |
| 03/27 | Auburn 5, South Carolina 3 | | | Columbia, SC | SEC | |
| 03/28 | Auburn 11, South Carolina 3 | | | Columbia, SC | SEC | |
| 03/30 | #22 North Carolina 17, South Carolina 7 | | | Chapel Hill, NC | | |
| 04/02 | #16 Tennessee 9, South Carolina 1 | | | Columbia, SC | SEC | |
| 04/03 | #16 Tennessee 3, South Carolina 1 | | | Columbia, SC | SEC | |
| 04/03 | #16 Tennessee 8, South Carolina 0 | | | Columbia, SC | SEC | |
| 04/06 | USC-Upstate 6, South Carolina 0 | | | Columbia, SC | | |
| 04/10 | Kentucky 11, South Carolina 3 | | | Lexington, KY | SEC | |
| 04/10 | Kentucky 4, South Carolina 3 | | | Lexington, KY | SEC | |
| 04/11 | Kentucky 8, South Carolina 0 | | | Lexington, KY | SEC | |
| 04/14 | USC-Upstate 5, South Carolina 0 | | | Spartanburg, SC | | |
| 04/17 | Mississippi State 2, South Carolina 1 | | | Columbia, SC | SEC | |
| 04/17 | South Carolina 8, Mississippi State 4 | | | Columbia, SC | SEC | |
| 04/18 | Mississippi State 3, South Carolina 1 | | | Columbia, SC | SEC | |
| 04/21 | Coastal Carolina 4, South Carolina 3 | | | Columbia, SC | | |
| 04/24 | #12 Georgia 9, South Carolina 8 | | | Athens, GA | SEC | |
| 04/24 | #12 Georgia 3, South Carolina 1 | | | Athens, GA | SEC | |
| 04/25 | #12 Georgia 10, South Carolina 2 | | | Athens, GA | SEC | |
| 05/08 | #6 Florida 20, South Carolina 0 | | | Gainesville, FL | SEC | |
| 05/08 | #6 Florida 6, South Carolina 1 | | | Gainesville, FL | SEC | |
| 05/09 | #6 Florida 9, South Carolina 0 | | | Gainesville, FL | SEC | |